Partecipanti: Professor Emanuele Paci: Astbury Centre for Structural Molecular Biology, Università di Leeds (UK)
Abstract
The fast development of advanced experimental probes, including single molecule ones, is revolutionising the study of complex biomolecular systems. Properties that have become measurable provide an opportunity to test theories and models. I will show how computational methods and simulations are valuable tools assess the validity of theories and the interpretability of experiments.
I will present methods developed in my group to answer questions raised by experiments and investigate structure and dynamics of proteins in different contexts, with a particular focus on single molecule force probes and mass spectrometry measurements